Biodegradable and biocompatible exceedingly small magnetic iron oxide nanoparticles for T₁-weighted magnetic resonance imaging of tumors.

ABSTRACT: Magnetic resonance imaging (MRI) has been widely using in clinical diagnosis, and contrast agents (CAs) can improve the sensitivity MRI. To overcome the problems of commercial Gd chelates-based T₁ CAs, commercial magnetic iron oxide nanoparticles (MIONs)-based T₂ CAs, and reported exceedingly small MIONs (ES-MIONs)-based T₁ CAs, in this study, a facile co-precipitation method was developed to synthesize biodegradable and biocompatible ES-MIONs with excellent water-dispersibility using poly (aspartic acid) (PASP) as a stabilizer for T₁-weighted MRI of tumors. After optimization of the synthesis conditions, the final obtained ES-MION9 with 3.7 nm of diameter has a high r₁ value (7.0 ± 0.4 mM^-1 s^-1) and a low r₂

SUBMITTER: Lu X 

PROVIDER: S-EPMC9338602 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature