Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice.

ABSTRACT:

Background and aims

Liver fibrosis (LF) is a central pathological process that occurs in most types of chronic liver diseases. Advanced LF causes cirrhosis, hepatocellular carcinoma, and liver failure. However, the exact molecular mechanisms underlying the initiation and progression of LF remain largely unknown.

Approach and results

This study was designed to investigate the role of protein kinase D3 (PKD3; gene name Prkd3) in the regulation of liver homeostasis. We generated global Prkd3 knockout (Prkd3^-/- ) mice and myeloid-cell-specific Prkd3 knockout (Prkd3^∆LysM ) mice, and we found that both Prkd3^-/- mice and Prkd3^∆LysM mice displayed spontaneous LF. PKD3 deficiency also aggravated CCl₄ -induced LF. PKD3 is highly e

SUBMITTER: Zhang S 

PROVIDER: S-EPMC9338785 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature