Anti-invasive effects of minoxidil on human breast cancer cells: combination with ranolazine.

ABSTRACT: A plethora of ion channels have been shown to be involved systemically in the pathophysiology of cancer and ion channel blockers can produce anti-metastatic effects. However, although ion channels are known to frequently function in concerted action, little is known about possible combined effects of ion channel modulators on metastatic cell behaviour. Here, we investigated functional consequences of pharmacologically modulating ATP-gated potassium (K_ATP) channel and voltage-gated sodium channel (VGSC) activities individually and in combination. Two triple-negative human breast cancer cell lines were used: MDA-MB-231 and MDA-MB-468, the latter mainly for comparison. Most experiments were carried out on hypoxic cells. Electrophysiological effects were studied by whole-cell patch

SUBMITTER: Qiu S 

PROVIDER: S-EPMC9338910 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature