Multivariate genome-wide association study of depression, cognition, and memory phenotypes and validation analysis identify 12 cross-ethnic variants.

ABSTRACT: To date, little is known about the pleiotropic genetic variants among depression, cognition, and memory. The current research aimed to identify the potential pleiotropic single nucleotide polymorphisms (SNPs), genes, and pathways of the three phenotypes by conducting a multivariate genome-wide association study and an additional pleiotropy analysis among Chinese individuals and further validate the top variants in the UK Biobank (UKB). In the discovery phase, the participants were 139 pairs of dizygotic twins from the Qingdao Twins Registry. The genome-wide efficient mixed-model analysis identified 164 SNPs reaching suggestive significance (P < 1 × 10^-5). Among them, rs3967317 (P = 1.21 × 10^-8) exceeded the genome-wide significance level (P < 5 × 10^-8) and

SUBMITTER: Sun J 

PROVIDER: S-EPMC9338946 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature