DeepPVC: prediction of a partial volume-corrected map for brain positron emission tomography studies via a deep convolutional neural network.

ABSTRACT:

Background

Partial volume correction with anatomical magnetic resonance (MR) images (MR-PVC) is useful for accurately quantifying tracer uptake on brain positron emission tomography (PET) images. However, MR segmentation processes for MR-PVC are time-consuming and prevent the widespread clinical use of MR-PVC. Here, we aimed to develop a deep learning model to directly predict PV-corrected maps from PET and MR images, ultimately improving the MR-PVC throughput.

Methods

We used MR T1-weighted and [¹¹C]PiB PET images as input data from 192 participants from the Alzheimer's Disease Neuroimaging Initiative database. We calculated PV-corrected maps as the training target using the region-based voxel-wise PVC method. Two-dimensional U-Net model was trained and validated

SUBMITTER: Matsubara K 

PROVIDER: S-EPMC9339068 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature