Immune Targeted Therapies for COVID-19 Infection: A Narrative Review.

ABSTRACT: In December 2019, the coronavirus disease-2019 (COVID-19) outbreak emerged in Wuhan, China. The World Health Organization officially declared it a pandemic on March 11, 2020. Reports indicated that the associated mortality of the infection is quite higher in the elderly, individuals with specific comorbidities (such as diabetes mellitus), and generally the ones with a compromised immune system. A cohort study in Wuhan, China, reported a dysregulated immune response in 452 patients with laboratory-confirmed COVID-19. As a result of this suppressed immune response, an increase in neutrophil to lymphocyte ratio, T lymphopenia, and a decrease in CD4⁺ T cells were all common laboratory findings, especially in severe cases. On the other hand, there is substantial evidence of T cell ex

SUBMITTER: Forouzani-Haghighi B 

PROVIDER: S-EPMC9339106 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature