Drug resistant Mycobacterium tuberculosis in Oman: resistance-conferring mutations and lineage diversity.

ABSTRACT:

Background

The Sultanate of Oman is country a low TB-incidence, with less than seven cases per 10⁵ population detected in 2020. Recent years have witnessed a persistence in TB cases, with sustained incidence rate among expatriates and limited reduction among Omanis. This pattern suggests transmission from the migrant population. The present study examined the genetic profile and drug resistance-conferring mutations in Mycobacterium tuberculosis collected from Omanis and expatriates to recognise possible causes of disease transmission.

Methods

We examined M. tuberculosis cultured positive samples, collected from Omanis (n = 1,344) and expatriates (n = 1,203) between 2009 and 2018. These isolates had a known in vitro susceptibility

SUBMITTER: Al Mahrouqi S 

PROVIDER: S-EPMC9339217 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature