Population genetics of polymorphism and divergence in rapidly evolving populations.

ABSTRACT: In rapidly evolving populations, numerous beneficial and deleterious mutations can arise and segregate within a population at the same time. In this regime, evolutionary dynamics cannot be analyzed using traditional population genetic approaches that assume that sites evolve independently. Instead, the dynamics of many loci must be analyzed simultaneously. Recent work has made progress by first analyzing the fitness variation within a population, and then studying how individual lineages interact with this traveling fitness wave. However, these "traveling wave" models have previously been restricted to extreme cases where selection on individual mutations is either much faster or much slower than the typical coalescent timescale Tc. In this work, we show how the traveling wave framework ca

SUBMITTER: Melissa MJ 

PROVIDER: S-EPMC9339298 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature