Histone variant H2A.Z promotes meiotic chromosome axis organization in Saccharomyces cerevisiae.

ABSTRACT: Progression through meiosis is associated with significant reorganization of chromosome structure, regulated in part by changes in histones and chromatin. Prior studies observed defects in meiotic progression in yeast strains lacking the linker histone H1 or variant histone H2A.Z. To further define the contributions of these chromatin factors, we have conducted genetic and cytological analysis of cells undergoing meiosis in the absence of H1 and H2A.Z. We find that a spore viability defect observed in strains lacking H2A.Z can be partially suppressed if cells also lack histone H1, while the combined loss of both H1 and H2A.Z is associated with elevated gene conversion events. Cytological analysis of Red1 and Rec8 staining patterns indicates that a subset of cells lacking H2A.Z fail to asse

SUBMITTER: Chigweshe L 

PROVIDER: S-EPMC9339299 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature