Evolutionary jumps in bacterial GC content.

ABSTRACT: Genomic GC (Guanine-Cytosine) content is a fundamental molecular trait linked with many key genomic features such as codon and amino acid use. Across bacteria, GC content is surprisingly diverse and has been studied for many decades; yet its evolution remains incompletely understood. Since it is difficult to observe GC content evolve on laboratory time scales, phylogenetic comparative approaches are instrumental; but this dimension is rarely studied systematically in the case of bacterial GC content. We applied phylogenetic comparative models to analyze GC content evolution in multiple bacterial groups across 2 major bacterial phyla. We find that GC content diversifies via a combination of gradual evolution and evolutionary "jumps." Surprisingly, unlike prior reports that solely focused on

SUBMITTER: Mahajan S 

PROVIDER: S-EPMC9339322 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature