The effect of histologic grade on neoadjuvant treatment outcomes in esophageal cancer.

ABSTRACT:

Background and objectives

The gold standard for locoregional esophageal cancer (LEC) treatment includes preoperative chemoradiation and surgical resection, with possible perioperative or adjuvant systemic therapy. With few data associating histologic grade and prognosis in LEC patients receiving neoadjuvant chemoradiation followed by resection, we seek to evaluate this association.

Methods

Our institutional esophagectomy database between 1999 and 2019 was queried, selecting esophageal adenocarcinoma patients who completed neoadjuvant therapy (NAT), followed by esophagectomy. Propensity-score matching of low- and high-histologic grade groups was performed to assess survival metrics using initial clinical grade (cG) and final pathologic grade (pG). We performed a multivariable

SUBMITTER: Pointer DT 

PROVIDER: S-EPMC9339510 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature