Fibrinogen and Factor XIII in Venous Thrombosis and Thrombus Stability.
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ABSTRACT:
SUBMITTER: Wolberg AS
PROVIDER: S-EPMC9339521 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
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Fibrinogen and Factor XIII in Venous Thrombosis and Thrombus Stability.
Wolberg Alisa S AS Sang Yaqiu Y
Arteriosclerosis, thrombosis, and vascular biology 20220602 8
As the third most common vascular disease, venous thromboembolism is associated with significant mortality and morbidity. Pathogenesis underlying venous thrombosis is still not fully understood. Accumulating data suggest fibrin network structure and factor XIII-mediated crosslinking are major determinants of venous thrombus mass, composition, and stability. Understanding the cellular and molecular mechanisms mediating fibrin(ogen) and factor XIII production and function and their ability to infl ...[more]
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