Deposition chamber technology as building blocks for a standardized brain-on-chip framework.

ABSTRACT: The in vitro modeling of human brain connectomes is key to exploring the structure-function relationship of the central nervous system. Elucidating this intricate relationship will allow better studying of the pathological mechanisms of neurodegeneration and hence result in improved drug screenings for complex neurological disorders, such as Alzheimer's and Parkinson diseases. However, currently used in vitro modeling technologies lack the potential to mimic physiologically relevant neural structures. Herein, we present an innovative microfluidic design that overcomes one of the current limitations of in vitro brain models: their inability to recapitulate the heterogeneity of brain regions in terms of cellular density and number. This device allows the controlled and uniform deposition of

SUBMITTER: Maisonneuve BGC 

PROVIDER: S-EPMC9339542 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature