Hematogenous dissemination of pathogenic and non-pathogenic Leptospira in a short-term murine model of infection.

ABSTRACT: Leptospirosis is an emerging zoonosis caused by pathogenic Leptospira spp. Because rodents are natural hosts of Leptospira, rodent models of pathogenesis have been limited, but are valuable to understand infection in reservoir animals even in the absence of disease. Mouse models of infection provide advantages due to genetic tractability, so developing murine models of Leptospira infection is crucial for further understanding the biology of this organism. Previously our laboratory developed a short-term murine model of Borrelia burgdorferi hematogenous dissemination to investigate the role of adhesion proteins on bacterial survival and dissemination within a host. Here we adapt this model to Leptospira. C3H/HeJ mice are anesthetized, inoculated intravenou

SUBMITTER: Surdel MC 

PROVIDER: S-EPMC9339599 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature