SARS-CoV-2-Specific Adaptive Immunity in COVID-19 Survivors With Asthma.

ABSTRACT:

Background

Asthma patients potentially have impaired adaptive immunity to virus infection. The levels of SARS-CoV-2-specific adaptive immunity between COVID-19 survivors with and without asthma are presently unclear.

Methods

COVID-19 survivors (patients with asthma n=11, with allergies n=8, and COVID-19 only n=17) and non-COVID-19 individuals (asthmatic patients n=10 and healthy controls n=9) were included. The COVID-19 patients were followed up at about 8 months and 16 months after discharge. The clinical characteristics, lymphocyte subsets, memory T cells, and humoral immunity including SARS-CoV-2 specific antibodies, SARS-CoV-2 pseudotyped virus neutralization assay, and memory B cells were analyzed in these subjects.

Results

The strength of virus-specific T cell r

SUBMITTER: Chen L 

PROVIDER: S-EPMC9339657 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature