Use of transcriptomics in hazard identification and next generation risk assessment: A case study with clothianidin.

ABSTRACT: Toxicological risk assessment is essential in the evaluation and authorization of different classes of chemical substances. Genotoxicity and mutagenicity testing are of highest priority and rely on established in vitro systems with bacterial and mammalian cells, sometimes followed by in vivo testing using rodent animal models. Transcriptomic approaches have recently also shown their value to determine transcript signatures specific for genotoxicity. Here, we studied how transcriptomic data, in combination with in vitro tests with human cells, can be used for the identification of genotoxic properties of test compounds. To this end, we used liver samples from a 28-day oral toxicity study in rats with the pesticidal active substances imazalil, thiacloprid, and clothianidin, a neonicotinoid-t

SUBMITTER: Sprenger H 

PROVIDER: S-EPMC9339662 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature