Prevalence of osteopathologies in a single center cohort of survivors of childhood primary brain tumor.

ABSTRACT:

Background

Childhood primary brain tumors (CPBT) are the second largest group of childhood malignancies and associated with a high risk for endocrine late effects.

Objective

To assess endocrine late effects and their relevance for the development of osteopathologies in survivors.

Methods

This single center cross sectional study investigated data from 102 CPBT survivors with a mean age of 13.0 years and a mean age at diagnosis of 8.7 years. Clinical, biochemical, radiographic, and anamnestic data regarding endocrine and bone health were obtained at study visits. In addition, data regarding tumor stage and therapy was obtained by chart review. An expert opinion was applied to define presence of osteopathologies.

Results

Impaired bone health, defined by at least o

SUBMITTER: Schundeln MM 

PROVIDER: S-EPMC9339690 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature