Association between dried fruit intake and pan-cancers incidence risk: A two-sample Mendelian randomization study.

ABSTRACT:

Background

Observational studies have revealed that dried fruit intake may be associated with cancer incidence; however, confounding factors make the results prone to be disturbed. Therefore, we conducted a two-sample Mendelian randomization (MR) study to explore the causal relationship between dried fruit intake and 11 site-specific cancers.

Materials and methods

Forty-three single nucleoside polymers (SNPs) with robust genome-wide association study (GWAS) evidence, strongly correlated with dried fruit intake, were used as instrumental variables (IVs) in this study. The summary-level genetic datasets of site-specific cancers were obtained from the Oncoarray oral cavity and oropharyngeal cancer consortium, International Lung Cancer Consortium, Breast Cancer Association Conso

SUBMITTER: Jin C 

PROVIDER: S-EPMC9339715 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature