The acquisition of humoral immune responses targeting <i>Plasmodium falciparum</i> sexual stages in controlled human malaria infections.

ABSTRACT: Individuals infected with P. falciparum develop antibody responses to intra-erythrocytic gametocyte proteins and exported gametocyte proteins present on the surface of infected erythrocytes. However, there is currently limited knowledge on the immunogenicity of gametocyte antigens and the specificity of gametocyte-induced antibody responses. In this study, we assessed antibody responses in participants of two controlled human malaria infection (CHMI) studies by ELISA, multiplexed bead-based antibody assays and protein microarray. By comparing antibody responses in participants with and without gametocyte exposure, we aimed to disentangle the antibody response induced by asexual and sexual stage parasites. We showed that after a single malaria infection, a significant anti-sexual sta

SUBMITTER: de Jong RM 

PROVIDER: S-EPMC9339717 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature