Electronically monitored medication adherence in idiopathic pulmonary fibrosis: prevalence, predictors and outcomes.

ABSTRACT: Medication adherence studies in idiopathic pulmonary fibrosis (IPF) are limited, use cross-sectional designs and report discontinuation rates. We prospectively investigated adherence to pirfenidone in IPF patients using electronic monitoring, which provides insights on whether and when the medication was taken on a day-by-day basis. We investigated the impact of nonadherence on lung function and selected predictors for nonadherence based on the COM-B behavioural model. The longitudinal statistical analyses included generalised estimation equations and linear mixed effects models. 55 patients initiating pirfenidone were followed-up for 2 years after diagnosis (76.4% men, mean age 71.1 years (range 50-87 years), mean forced vital capacity (FVC) 88% predicted (sd 18.3), mean diffusing capacit

SUBMITTER: Delameillieure A 

PROVIDER: S-EPMC9339768 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature