Transcriptional Down-Regulation of Major Histocompatibility Complex as a Possible Pathogenesis for Meniere's Disease.

ABSTRACT:

Objectives

This study aimed to determine the underlying pathogenesis of Meniere's disease (MD) using transcriptome analysis.

Methods

Total RNA was extracted from the peripheral blood mononuclear cells of 39 patients with MD and 39 controls. Through microarray analysis for nine patients and controls, the differentially expressed genes (DEGs) of those two groups were screened based on cut-off criteria (|fold changes| > 2.0 and adjusted p-value < 0.05). The functional enrichment analysis of DEGs was performed using Gene Ontology (GO).

Results

There were 996 DEGs identified in the MD group: 415 were upregulated and 581 were downregulated. A functional enrichment analysis indicated that the downregulated DEGs were significantly enriched in terms related to immune sy

SUBMITTER: Choi KD 

PROVIDER: S-EPMC9339969 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature