Routine lung volume recruitment in boys with Duchenne muscular dystrophy: a randomised clinical trial.

ABSTRACT:

Background

Impaired cough results in airway secretion retention, atelectasis and pneumonia in individuals with Duchenne muscular dystrophy (DMD). Lung volume recruitment (LVR) stacks breaths to inflate the lungs to greater volumes than spontaneous effort. LVR is recommended in DMD clinical care guidelines but is not well studied. We aimed to determine whether twice-daily LVR, compared with standard of care alone, attenuates the decline in FVC at 2 years in boys with DMD.

Methods

In this multicentre, assessor-blinded, randomised controlled trial, boys with DMD, aged 6-16 years with FVC >30% predicted, were randomised to receive conventional treatment or conventional treatment plus manual LVR twice daily for 2 years. The primary outcome was FVC % predicted at 2 years, adjusted

SUBMITTER: Katz SL 

PROVIDER: S-EPMC9340020 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature