Stress-related hippocampus activation mediates the association between polyvictimization and trait anxiety in adolescents.

ABSTRACT: Early life stress exposures are associated with adverse health outcomes and heightened anxiety symptoms in adolescents. Stress-sensitive brain regions like the hippocampus and amygdala are particularly impacted by early life adversities and are also implicated in the development of anxiety disorders. However, to date, no studies have specifically examined the neural correlates of polyvictimization (exposure to multiple categories of victimization) or the contribution of stress-sensitive neural nodes to polyvictimization's impact on mental health. To elucidate these relationships, the current study analyzed associations between polyvictimization, hippocampal and amygdalar activation during an acute stress task and trait anxiety in a sample of 80 children and adolescents aged 9-16 years (33

SUBMITTER: Corr R 

PROVIDER: S-EPMC9340110 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature