ML323 suppresses the progression of ovarian cancer via regulating USP1-mediated cell cycle.

ABSTRACT: Background: Ubiquitin specific protease 1 (USP1) tightly correlates with poor prognosis of multiple cancers. However, whether USP1 underlies ovarian cancer (OV) progression remains unclarified. Methods: First, GSEA strategy and WGCNA analysis were used to screen for anti-ovarian cancer drugs and furthern optimal module, respectively. In addition, functional enrichments of module genes were realized by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Kaplan-Meier was then employed to analyze the prognostic impact of USP1 expression on OV patients. Cell proliferation and cell cycle assays were used to confirm biological functions of USP1 in the final. Results: Through the forementioned methods, we obtained five candidate

SUBMITTER: Song B 

PROVIDER: S-EPMC9340375 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature