Risk of ischaemic stroke among new users of glucosamine and chondroitin sulphate: a nested case-control study.

ABSTRACT:

Background

Several studies have reported that the use of chondroitin sulphate (CS) and glucosamine may reduce the risk of acute myocardial infarction. Although it is thought that this potential benefit could be extended to ischaemic stroke (IS), the evidence is scarce.

Objective

To test the hypothesis that the use of prescription glucosamine or CS reduces the risk of IS.

Design

Case-control study nested in an open cohort.

Methods

Patients aged 40-99 years registered in a Spanish primary healthcare database (BIFAP) during the 2002-2015 study period. From this cohort, we identified incident cases of IS, applying a case-finding algorithm and specific validation procedures, and randomly sampled five controls per case, individually matched with cases by exact age, g

SUBMITTER: Mazzucchelli R 

PROVIDER: S-EPMC9340380 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature