Sexual dimorphism in prostacyclin-mimetic responses within rat mesenteric arteries: A novel role for K_V 7.1 in shaping IP receptor-mediated relaxation.

ABSTRACT:

Background and purpose

Prostacyclin mimetics express potent vasoactive effects via prostanoid receptors that are not unequivocally defined, as to date no study has considered sex as a factor. The aim of this study was to determine the contribution of IP and EP₃ prostanoid receptors to prostacyclin mimetic iloprost-mediated responses, whether K_V 7.1-5 channels represent downstream targets of selective prostacyclin-IP-receptor agonist MRE-269 and the impact of the oestrus cycle on vascular reactivity.

Experimental approach

Within second-order mesenteric arteries from male and female Wistar rats, we determined (1) relative mRNA transcripts for EP_1-4 (Ptger_1-4 ), IP (Ptgi) and TXA₂ (Tbxa) prostanoid receptors via RT-qPCR; (2

SUBMITTER: Baldwin SN 

PROVIDER: S-EPMC9340493 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature