A population study of clinical trial accrual for women and minorities in neuro-oncology following the NIH Revitalization Act.

ABSTRACT:

Background

The NIH Revitalization Act, implemented 29 years ago, set to improve the representation of women and minorities in clinical trials. In this study, we investigate progress made in all phase therapeutic clinical trials for neuroepithelial CNS tumors stratified by demographic-specific age-adjusted disease incidence and mortality. Additionally, we identify workforce characteristics associated with clinical trials meeting established accrual benchmarks.

Methods

Registry study of published clinical trials for World Health Organization defined neuroepithelial CNS tumors between January 2000 and December 2019. Study participants were obtained from PubMed and ClinicalTrials.gov. Population-based data originated from the CBTRUS for incidence analyses. SEER-18 Incidence-Base

SUBMITTER: Reihl SJ 

PROVIDER: S-EPMC9340618 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature