Therapeutic Potential and Activity Modulation of the Protein Lysine Deacylase Sirtuin 5.

ABSTRACT: Sirtiun 5 (SIRT5) is a NAD⁺-dependent protein lysine deacylase primarily located in mitochondria. SIRT5 displays an affinity for negatively charged acyl groups and mainly catalyzes lysine deglutarylation, desuccinylation, and demalonylation while possessing weak deacetylase activity. SIRT5 substrates play crucial roles in metabolism and reactive oxygen species (ROS) detoxification, and SIRT5 activity is protective in neuronal and cardiac physiology. Moreover, SIRT5 exhibits a dichotomous role in cancer, acting as context-dependent tumor promoter or suppressor. Given its multifaceted activity, SIRT5 is a promising target in the design of activators or inhibitors that might act as therapeutics in many pathologies, including cancer, cardiovascular disorders, and neurodegeneration.

SUBMITTER: Fiorentino F 

PROVIDER: S-EPMC9340778 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature