Prospective associations between vitamin D and depression in middle-aged adults: findings from the UK Biobank cohort.

ABSTRACT:

Background

A possible role of vitamin D in the pathophysiology of depression is currently speculative, with more rigorous research needed to assess this association in large adult populations. The current study assesses prospective associations between vitamin D status and depression in middle-aged adults enrolled in the UK Biobank.

Methods

We assessed prospective associations between vitamin D status at the baseline assessment (2006-2010) and depression measured at the follow-up assessment (2016) in 139 128 adults registered with the UK Biobank.

Results

Amongst participants with no depression at baseline (n = 127 244), logistic regression revealed that those with vitamin D insufficiency [adjusted odds ratio (aOR) = 1.14, 95% confidence interval (CI) = 1.07-1.2

SUBMITTER: Ronaldson A 

PROVIDER: S-EPMC9340850 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature