GPCR genes as a predictor of glioma severity and clinical outcome.

ABSTRACT:

Objective

To undertake a comprehensive analysis of the differential expression of the G protein-coupled receptor (GPCR) genes in order to construct a GPCR gene signature for human glioma prognosis.

Methods

This current study investigated several glioma transcriptomic datasets and identified the GPCR genes potentially associated with glioma severity.

Results

A gene signature comprising 13 GPCR genes (nine upregulated and four downregulated genes in high-grade glioma) was developed. The predictive power of the 13-gene signature was tested in two validation cohorts and a strong positive correlation (Spearman's rank correlation test: ρ = 0.649 for the Validation1 cohort; ρ = 0.693 for the Validation2 cohort) was observed be

SUBMITTER: Ko EA 

PROVIDER: S-EPMC9340954 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature