Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity.

ABSTRACT: The immunosuppressive function of regulatory T (T_reg) cells is dependent on continuous expression of the transcription factor Foxp3. Foxp3 loss of function or induced ablation of T_reg cells results in a fatal autoimmune disease featuring all known types of inflammatory responses with every manifestation stemming from T_reg cell paucity, highlighting a vital function of T_reg cells in preventing fatal autoimmune inflammation. However, a major question remains whether T_reg cells can persist and effectively exert their function in a disease state, where a broad spectrum of inflammatory mediators can either inactivate T_reg cells or render innate and adaptive pro-inflammatory effector cells insensitive to suppression. By reinstatin

SUBMITTER: Hu W 

PROVIDER: S-EPMC9341271 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature