Leukocyte transcriptome indicators of development of infection in kidney transplant recipients.

ABSTRACT: After kidney transplantation, infection and death are important clinical complications, especially for the growing numbers of older patients with limited resilience to withstand adverse events. Evaluation of changes in gene expression in immune cells can reveal the underlying mechanisms behind vulnerability to infection. A cohort of 60 kidney transplant recipients was evaluated. Gene expression in peripheral blood mononuclear cells 3 months after kidney transplantation was analyzed to compare differences between patients with infection and those who were infection-free in the first-year post-transplant. Pro-inflammatory genes such as IL1B, CCL4, and TNF were found to be downregulated in post-transplant PBMC from patients who developed infection. In contrast, genes involved in metabolism, H

SUBMITTER: Schaenman JM 

PROVIDER: S-EPMC9341289 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature