Application of fluoride disturbs plaque microecology and promotes remineralization of enamel initial caries.

ABSTRACT:

Background

The caries-preventive effect of topical fluoride application has been corroborated by a number of clinical studies. However, the effect of fluoride on oral microecology remains unclear.

Objective

To monitor the effect of fluoride on dental plaque microecology and demineralization/remineralization balance of enamel initial caries.

Methods

Three-year-old children were enrolled and treated with fluoride at baseline and 6 months. International Caries Detection and Assessment System II indices of 52 subjects were measured at baseline, 3, 6, and 12 months. Supragingival plaque samples of 12 subjects were collected at baseline, 3 and 14 days for 16S rRNA sequencing.

Results

Changes in microbial community structure were observed at 3 days after fluoridation.

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC9341347 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature