A facile method for anti-cancer drug encapsulation into polymersomes with a core-satellite structure.

ABSTRACT: Polymersomes possess the self-assembly vesicular structure similar to liposomes. Although a variety of comparisons between polymersomes and liposomes in the aspects of physical properties, preparation and applications have been elaborated in many studies, few focus on their differences in drug encapsulation, delivery and release in vitro and in vivo. In the present work, we have provided a modified direct hydration method to encapsulate anti-cancer drug paclitaxel (PTX) into PEG-b-PCL constituted polymersomes (PTX@PS). In addition to advantages including narrow particle size distribution, high colloid stability and moderate drug-loading efficiency, we find that the loaded drug aggregate in small clusters and reside through the polymersome membrane, representing a uniqu

SUBMITTER: Xu H 

PROVIDER: S-EPMC9341360 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature