Broad sarbecovirus neutralization by a human monoclonal antibody.

ABSTRACT: The recent emergence of SARS-CoV-2 variants of concern^1-10 and the recurrent spillovers of coronaviruses^11,12 into the human population highlight the need for broadly neutralizing antibodies that are not affected by the ongoing antigenic drift and that can prevent or treat future zoonotic infections. Here we describe a human monoclonal antibody designated S2X259, which recognizes a highly conserved cryptic epitope of the receptor-binding domain and cross-reacts with spikes from all clades of sarbecovirus. S2X259 broadly neutralizes spike-mediated cell entry of SARS-CoV-2, including variants of concern (B.1.1.7, B.1.351, P.1, and B.1.427/B.1.429), as well as a wide spectrum of human and potentially zoonotic sarbecoviruses through inhibition of angiotensin-converting en

SUBMITTER: Tortorici MA 

PROVIDER: S-EPMC9341430 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature