Screening of ferroptosis-related genes in sepsis-induced liver failure and analysis of immune correlation.

ABSTRACT:

Purpose

Sepsis-induced liver failure is a kind of liver injury with a high mortality, and ferroptosis plays a key role in this disease. Our research aims to screen ferroptosis-related genes in sepsis-induced liver failure as targeted therapy for patients with liver failure.

Methods

Using the limma software, we analyzed the differentially expressed genes (DEGs) in the GSE60088 dataset downloaded from the Gene Expression Omnibus (GEO) database. Clusterprofiler was applied for enrichment analysis of DEGs enrichment function. Then, the ferroptosis-related genes of the mice in the FerrDb database were crossed with DEGs. Sepsis mice model were prepared by cecal ligation and perforation (CLP). ALT and AST in the serum of mice were measured using detection kit. The pathological chan

SUBMITTER: Chen Q 

PROVIDER: S-EPMC9341447 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature