Zebrafish transposable elements show extensive diversification in age, genomic distribution, and developmental expression.

ABSTRACT: There is considerable interest in understanding the effect of transposable elements (TEs) on embryonic development. Studies in humans and mice are limited by the difficulty of working with mammalian embryos and by the relative scarcity of active TEs in these organisms. The zebrafish is an outstanding model for the study of vertebrate development, and over half of its genome consists of diverse TEs. However, zebrafish TEs remain poorly characterized. Here we describe the demography and genomic distribution of zebrafish TEs and their expression throughout embryogenesis using bulk and single-cell RNA sequencing data. These results reveal a highly dynamic genomic ecosystem comprising nearly 2000 distinct TE families, which vary in copy number by four orders of magnitude and span a wide range o

SUBMITTER: Chang NC 

PROVIDER: S-EPMC9341512 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature