Role of 5HT1A Receptors in the Neuroprotective and Behavioral Effects of Cannabidiol in Hypoxic-Ischemic Newborn Piglets.

ABSTRACT: Background: Hypoxic-ischemic (HI) insults have important deleterious consequences in newborns, including short-term morbidity with neuromotor and cognitive disturbances. Cannabidiol (CBD) has demonstrated robust neuroprotective effects and shows anxiolytic/antidepressant effects as well. These effects are thought to be related to serotonin 5-HT_1A receptor (5HT_1AR) activation. We hereby aimed to study the role of 5HT_1AR in the neuroprotective and behavioral effects of CBD in HI newborn piglets. Methods: 1-day-old piglets submitted to 30 min of hypoxia (FiO2 10%) and bilateral carotid occlusion were then treated daily with vehicle, CBD 1 mg/kg, or CBD with the 5HT_1AR antagonist WAY 100635 1 mg/kg 72 h post-HI piglets were studied usin

SUBMITTER: Barata L 

PROVIDER: S-EPMC9341521 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature