A mechanistic model of ADHD as resulting from dopamine phasic/tonic imbalance during reinforcement learning.

ABSTRACT: Attention deficit hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder in children. Although the involvement of dopamine in this disorder seems to be established, the nature of dopaminergic dysfunction remains controversial. The purpose of this study was to test whether the key response characteristics of ADHD could be simulated by a mechanistic model that combines a decrease in tonic dopaminergic activity with an increase in phasic responses in cortical-striatal loops during learning reinforcement. To this end, we combined a dynamic model of dopamine with a neurocomputational model of the basal ganglia with multiple action channels. We also included a dynamic model of tonic and phasic dopamine release and control, and a learning procedure driven by tonic and phasic

SUBMITTER: Veronneau-Veilleux F 

PROVIDER: S-EPMC9342605 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature