Myeloid CCR2 Promotes Atherosclerosis after AKI.

ABSTRACT:

Background

The risk of cardiovascular events rises after AKI. Leukocytes promote atherosclerotic plaque growth and instability. We established a model of enhanced remote atherosclerosis after renal ischemia-reperfusion (IR) injury and investigated the underlying inflammatory mechanisms.

Methods

Atherosclerotic lesions and inflammation were investigated in native and bone marrow-transplanted LDL receptor-deficient (LDLr^-/- ) mice after unilateral renal IR injury using histology, flow cytometry, and gene expression analysis.

Results

Aortic root atherosclerotic lesions were significantly larger after renal IR injury than in controls. A gene expression screen revealed enrichment for chemokines and their cognate receptors in aortas of IR-injured mice in e

SUBMITTER: Husing AM 

PROVIDER: S-EPMC9342642 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature