Estimating the timing of multiple admixture events using 3-locus linkage disequilibrium.

ABSTRACT: Estimating admixture histories is crucial for understanding the genetic diversity we see in present-day populations. Allele frequency or phylogeny-based methods are excellent for inferring the existence of admixture or its proportions. However, to estimate admixture times, spatial information from admixed chromosomes of local ancestry or the decay of admixture linkage disequilibrium (ALD) is used. One popular method, implemented in the programs ALDER and ROLLOFF, uses two-locus ALD to infer the time of a single admixture event, but is only able to estimate the time of the most recent admixture event based on this summary statistic. To address this limitation, we derive analytical expressions for the expected ALD in a three-locus system and provide a new statistical method based on these re

SUBMITTER: Liang M 

PROVIDER: S-EPMC9342778 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature