Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery.

ABSTRACT: Bariatric surgery is a sustainable weight loss approach, including vertical sleeve gastrectomy (VSG). Obesity exacerbates tumor growth, while diet-induced weight loss impairs progression. It remains unknown how bariatric surgery-induced weight loss impacts cancer progression or alters response to therapy. Using a pre-clinical model of obesity followed by VSG or diet-induced weight loss, breast cancer progression and immune checkpoint blockade therapy were investigated. Weight loss by VSG or weight-matched dietary intervention before tumor engraftment protected against obesity-exacerbated tumor progression. However, VSG was not as effective as diet in reducing tumor burden despite achieving similar weight and adiposity loss. Leptin did not associate with changes in tumor burden; however, ci

SUBMITTER: Sipe LM 

PROVIDER: S-EPMC9342954 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature