Engineered natural killer cells impede the immunometabolic CD73-adenosine axis in solid tumors.
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ABSTRACT:
SUBMITTER: Chambers AM
PROVIDER: S-EPMC9342955 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
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Engineered natural killer cells impede the immunometabolic CD73-adenosine axis in solid tumors.
Chambers Andrea M AM Lupo Kyle B KB Wang Jiao J Cao Jingming J Utturkar Sagar S Lanman Nadia N Bernal-Crespo Victor V Jalal Shadia S Pine Sharon R SR Torregrosa-Allen Sandra S Elzey Bennett D BD Matosevic Sandro S
eLife 20220711
Immunometabolic reprogramming due to adenosine produced by CD73 (encoded by the 5'-ectonucleotidase gene <i>NT5E</i>) is a recognized immunosuppressive mechanism contributing to immune evasion in solid tumors. Adenosine is not only known to contribute to tumor progression, but it has specific roles in driving dysfunction of immune cells, including natural killer (NK) cells. Here, we engineered human NK cells to directly target the CD73-adenosine axis by blocking the enzymatic activity of CD73. I ...[more]
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