Premortem anticoagulation timing and dose in donation after circulatory death: multicentre study of associations with graft function.

ABSTRACT:

Background

In controlled donation after circulatory determination of death (DCD), it is common to administer premortem heparin to potential donors. This practice remains controversial because there is limited evidence for it and there is the possibility of inducing hemorrhage. To our knowledge, no previous studies have assessed the effects of heparin timing and dose on graft function.

Methods

We performed a multicentre cohort study of consecutive DCD donors and the recipients of their organs. Anticoagulation administration was considered early if given near the time of withdrawal of life-sustaining measures and late if delayed until the onset of donor hypoxemia (oxygen saturation < 70%) or hypotension (systolic blood pressure < 60 mm Hg or mean blood pressure < 50 mm Hg). Th

SUBMITTER: Kramer AH 

PROVIDER: S-EPMC9343016 | biostudies-literature | 2022 Jul-Aug

REPOSITORIES: biostudies-literature