The latent dedifferentiation capacity of newt limb muscles is unleashed by a combination of metamorphosis and body growth.

ABSTRACT: Newts can regenerate their limbs throughout their life-span. Focusing on muscle, certain species of newts such as Cynops pyrrhogaster dedifferentiate muscle fibers in the limb stump and mobilize them for muscle creation in the regenerating limb, as they grow beyond metamorphosis. However, which developmental process is essential for muscle dedifferentiation, metamorphosis or body growth, is unknown. To address this issue, we tracked muscle fibers during limb regeneration under conditions in which metamorphosis and body growth were experimentally shifted along the axis of development. Our results indicate that a combination of metamorphosis and body growth is necessary for muscle dedifferentiation. On the other hand, ex vivo tracking of larval muscle fibers revealed that newt muscle fibers

SUBMITTER: Yu ZY 

PROVIDER: S-EPMC9343386 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature