Plasma levels of thrombin and activated protein C in patients with acute myocardial Infarction: An observational study.

ABSTRACT:

Introduction

Activation of the plasmatic coagulation system is a major contributor to acute myocardial infarction (AMI). Markers of plasmatic coagulation and thrombin activation are correlated with clinical, laboratory and outcome parameters. In this study, we sought to evaluate if the catalytically active coagulation factors thrombin and activated protein C (APC) can be measured in patients with AMI and whether there are associations with laboratory or clinical parameters.

Methods

Thrombin and APC was quantified using oligonucleotide-enzyme-capture assays (OECAs) in 132 patients presenting with AMI immediately before and 24 h after percutaneous coronary intervention (PCI).

Results

APC was measured above the lower limit of quantification (LLOQ) in 43 (32.6%) patients

SUBMITTER: Becher T 

PROVIDER: S-EPMC9343411 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature