Developmental modeling of hepatogenesis using obese iPSCs-hepatocyte differentiation uncovers pathological features.

ABSTRACT: Obesity is a multigene disorder. However, in addition to genetic factors, environmental determinants also participate in developing obesity and related pathologies. Thus, obesity could be best described as a combination of genetic and environmental perturbations often having its origin during the early developmental period. Environmental factors such as energy-dense food and sedentary lifestyle are known to be associated with obesogenicity. However, the combinatorial effects of gene-environment interactions are not well understood. Understanding the role of multiple genetic variations leading to subtle gene expression changes is not practically possible in monogenic or high-fat-fed animal models of obesity. In contrast, human induced pluripotent stem cells (hiPSCs) from individuals with fa

SUBMITTER: Varghese DS 

PROVIDER: S-EPMC9343434 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature