Rate of Successful Extubation in Mechanically Ventilated Patients with Cirrhosis and Hepatic Coma.

ABSTRACT:

Background

The prognosis of critically ill patients with cirrhosis who require mechanical ventilation is guarded. Data are lacking for the optimal therapeutic approach to hepatic encephalopathy (HE) in the ventilated patient.

Methods

Retrospective cohort analysis of 314 encounters (298 patients) with cirrhosis who underwent mechanical ventilation in a medical ICU and were ordered at least 1 dose of lactulose. Hazard of extubation alive was determined using a competing risk model. Primary exposures were HE therapy (lactulose and rifaximin) which were adjusted for the indication for ventilation (HE, procedures, respiratory failure), age, MELD-Na, and compensation status.

Results

Indications for ventilation were 22.3% for grade 4 HE, 29.9% for procedures, and 47.8% for r

SUBMITTER: Gibbs JT 

PROVIDER: S-EPMC9343472 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature