The cerebrospinal fluid proteome of preterm infants predicts neurodevelopmental outcome.

ABSTRACT:

Background

Survival rate increases for preterm infants, but long-term neurodevelopmental outcome predictors are lacking. Our primary aim was to determine whether a specific proteomic profile in cerebrospinal fluid (CSF) of preterm infants differs from that of term infants and to identify novel biomarkers of neurodevelopmental outcome in preterm infants.

Methods

Twenty-seven preterm infants with median gestational age 27 w + 4 d and ten full-term infants were enrolled prospectively. Protein profiling of CSF were performed utilizing an antibody suspension bead array. The relative levels of 178 unique brain derived proteins and inflammatory mediators, selected from the Human Protein Atlas, were measured.

Results

The CSF protein profile of preterm infants differed from th

SUBMITTER: Leifsdottir K 

PROVIDER: S-EPMC9343678 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature