Association between TPH1 polymorphisms and the risk of suicide behavior: An updated meta-analysis of 18,398 individuals.

ABSTRACT:

Objectives

We aimed to examine the association of TPH1 polymorphisms with the risk of suicide behavior (SB).

Design

Systematic review and meta-analysis.

Method

All relevant studies that evaluated the association between the A218C (rs1800532), A779C (rs1799913) and A6526G (rs4537731) polymorphisms and the susceptibility to SB published up to September 2021 were identified through a comprehensive systematic search in PubMed, Scopus, EBSCO and Science Direct electronic databases. The association between TPH1 gene polymorphisms and SB was evaluated using inherence models by odds ratio (OR) and 95% confidence interval (CI). Subgroup analyses, heterogeneity analyses, and publication bias were also tested in this meta-analysis.

Results

The meta-analysis

SUBMITTER: Genis-Mendoza AD 

PROVIDER: S-EPMC9343722 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature